Towards a proteome signature for invasive ductal breast carcinoma derived from label-free nanoscale LC-MS protein expression profiling of tumorous and glandular tissue.

@article{Rwer2009TowardsAP,
  title={Towards a proteome signature for invasive ductal breast carcinoma derived from label-free nanoscale LC-MS protein expression profiling of tumorous and glandular tissue.},
  author={Claudia R{\"o}wer and Johannes P C Vissers and Cornelia Koy and Marc Kipping and Michael Hecker and Toralf Reimer and Bernd Gerber and Hans-J{\"u}rgen Thiesen and Michael O. Glocker},
  journal={Analytical and bioanalytical chemistry},
  year={2009},
  volume={395 8},
  pages={2443-56}
}
As more and more alternative treatments become available for breast carcinoma, there is a need to stratify patients and individual molecular information seems to be suitable for this purpose. In this study, we applied label-free protein quantitation by nanoscale LC-MS and investigated whether this approach could be used for defining a proteome signature for invasive ductal breast carcinoma. Tissue samples from healthy breast and tumor were collected from three patients. Protein identifications… CONTINUE READING