Towards a proteome-scale map of the human protein–protein interaction network

  title={Towards a proteome-scale map of the human protein–protein interaction network},
  author={Jean-François Rual and Kavitha Venkatesan and Tong Hao and Tomoko Hirozane-Kishikawa and Am{\'e}lie Dricot and N. Li and G. Berriz and F. Gibbons and M. Dreze and N. Ayivi-Guedehoussou and Niels Klitgord and C. Simon and M. Boxem and S. Milstein and J. Rosenberg and D. S. Goldberg and Lan V. Zhang and S. L. Wong and G. Franklin and Siming Li and J. Albala and Janghoo Lim and Carlene Fraughton and E. Llamosas and Sebiha Cevik and Camille Bex and P. Lamesch and R. Sikorski and J. Vandenhaute and H. Zoghbi and A. Smolyar and S. Bosak and Reynaldo Sequerra and L. Doucette-Stamm and M. Cusick and D. Hill and F. Roth and Marc Vidal},
  • Jean-François Rual, Kavitha Venkatesan, +35 authors Marc Vidal
  • Published 2005
  • Biology, Medicine
  • Nature
  • Systematic mapping of protein–protein interactions, or ‘interactome’ mapping, was initiated in model organisms, starting with defined biological processes and then expanding to the scale of the proteome. Although far from complete, such maps have revealed global topological and dynamic features of interactome networks that relate to known biological properties, suggesting that a human interactome map will provide insight into development and disease mechanisms at a systems level. Here we… CONTINUE READING
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