Towards a new understanding on the regulation of mammalian oocyte meiosis resumption.

  title={Towards a new understanding on the regulation of mammalian oocyte meiosis resumption.},
  author={Qing-Yuan Sun and Yi-Liang Miao and Heide Schatten},
  journal={Cell cycle},
  volume={8 17},
Mammalian oocytes reach prophase of first meiosis around the time of birth, and remain at this stage for months or years, depending on the species. Only after puberty will the fully-grown oocytes begin to resume meiosis which is stimulated by gonadotropin surge. It has long been known that a high level of intra-oocyte cyclic adenosine 3',5'-monophosphate (cAMP) prevents oocyte meiosis resumption as indicated by germinal vesicle breakdown (GVBD). Recently, guanosine triphosphate-binding (G… CONTINUE READING


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