Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies

  title={Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies},
  author={Andrew C. Stanfield and Andrew M. McIntosh and Michael D. Spencer and Ruth C. M. Philip and Sonia Gaur and Stephen M. Lawrie},
  journal={European Psychiatry},
  pages={289 - 299}

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The neuroanatomy of ASD does not exist, but is highly age and gender dependent, and implications for approaches of stratification of ASD into more homogeneous subtypes are discussed.

Cerebellar volume in autism: Meta-analysis and analysis of the ABIDE cohort

A systematic meta-analysis of the literature suggested a weak but significant association between ASD diagnosis and increased cerebellar volume, but the analysis of the ABIDE cohort did not show any relationship.

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Adults with ASD have distributed differences in brain anatomy and connectivity that are associated with specific autistic features and traits, compatible with the concept of autism as a syndrome characterized by atypical neural "connectivity".

Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel‐based morphometry

Investigation of neuroanatomical differences between a homogenous group of young adults with autism of average intelligence but delayed or atypical language development relative to a closely matched group of typically developing controls revealed regional structural brain differences in brain areas implicated in social cognition, communication, and repetitive behaviors.

An Abnormal Cerebellar Network in Children with Autistic Spectrum Disorder:A Morphometric Study

Autism is a neurodevelopmental disorder characterized by poor social abilities, communication deficiency and restricted behavioural patterns. Recently, scholars started to consider the possibility of

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A volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders found that total vermis volume was decreased in the combined autism group and when examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls.

Pallidum and lateral ventricle volume enlargement in autism spectrum disorder




Brain anatomy and development in autism: review of structural MRI studies

Abnormal brain size effect on the thalamus in autism

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It is suggested that brain size is increased in autism and that differences are not generalized but appear to be the result of a pattern of enlargement with increases in the size of specific cortical lobes.

Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism.

The data suggest abnormalities in the anatomy and connectivity of limbic-striatal 'social' brain systems which may contribute to the brain metabolic differences and behavioural phenotype in autism.

An MRI study of the basal ganglia in autism

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It is found that frontal, temporal, and parietal white Matter volumes, as well as frontal and temporal gray matter volumes, changed at significantly slower rates in autism patients than in controls across the 2- to 11-year-age range.

Absence of magnetic resonance imaging evidence of pontine abnormality in infantile autism.

The reduced size of the neocerebellum in autism appears to be the result of maldevelopment within the cerebellum itself, a finding that is consistent with previous studies of neuropathologic specimens.

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Results suggest that ASP is on the mild end of the autism spectrum, and exploratory assessments of brain-IQ relationships reveal differences between HFA and ASP, indicating that these conditions may be neurodevelopmentally different when patterns of multiple measures are examined.