Towards a muscarinic hypothesis of schizophrenia


Although the neurotransmitter dopamine plays a prominent role in the pathogenesis and treatment of schizophrenia, the dopamine hypothesis of schizophrenia fails to explain all aspects of this disorder. It is increasingly evident that the pathology of schizophrenia also involves other neurotransmitter systems. Data from many streams of research including pre-clinical and clinical pharmacology, treatment studies, post-mortem studies and neuroimaging suggest an important role for the muscarinic cholinergic system in the pathophysiology of schizophrenia. This review will focus on evidence that supports the hypothesis that the muscarinic system is involved in the pathogenesis of schizophrenia and that muscarinic receptors may represent promising novel targets for the treatment of this disorder.

DOI: 10.1038/

Extracted Key Phrases

2 Figures and Tables

Citations per Year

2,352 Citations

Semantic Scholar estimates that this publication has 2,352 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Raedler2007TowardsAM, title={Towards a muscarinic hypothesis of schizophrenia}, author={Thomas J. Raedler and Frank P. Bymaster and Rajiv Tandon and David Leon Copolov and Brian Dean}, journal={Molecular Psychiatry}, year={2007}, volume={12}, pages={232-246} }