Towards a more comprehensive concept for prebiotics

@article{Bindels2015TowardsAM,
  title={Towards a more comprehensive concept for prebiotics},
  author={Laure B. Bindels and Nathalie M. Delzenne and Patrice D Cani and Jens Walter},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2015},
  volume={12},
  pages={303-310}
}
The essential role of the gut microbiota for health has generated tremendous interest in modulating its composition and metabolic function. One of these strategies is prebiotics, which typically refer to selectively fermented nondigestible food ingredients or substances that specifically support the growth and/or activity of health-promoting bacteria that colonize the gastrointestinal tract. In this Perspective, we argue that advances in our understanding of diet–microbiome–host interactions… 
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References

SHOWING 1-10 OF 120 REFERENCES
Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.
TLDR
By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Prebiotics: the concept revisited.
TLDR
A prebiotic is a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-being and health and the "dose argument" is not supported by the scientific data: it is misleading for consumers and should not be allowed.
Probiotic and prebiotic applications for vaginal health.
  • G. Reid
  • Biology, Medicine
    Journal of AOAC International
  • 2012
TLDR
In the future, probiotics and prebiotics will represent an important adjunct to pharmaceutical and other approaches used to care for feminine health.
Dietary prebiotics: current status and new definition
TLDR
This review sets the background for defining a dietary prebiotic as ‘‘a selectively fermented ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host health’’.
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
TLDR
Deep metagenomic sequencing analysis revealed that HFD and prebiotic treatment significantly affected the gut microbiome at different taxonomic levels and identified novel putative taxa and metabolic functions that may contribute to the development of or protection against the metabolic alterations observed during HFD feeding and HFD-Pre feeding.
Therapeutic modulation of intestinal dysbiosis.
Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
Background Alterations in the composition of gut microbiota - known as dysbiosis - has been proposed to contribute to the development of obesity, thereby supporting the potential interest of
The impact of the milk glycobiome on the neonate gut microbiota.
TLDR
The prebiotic effect of milk glycans has direct application to prevention of diseases such as necrotizing enterocolitis, a common and devastating disease of preterm infants.
...
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