Towards a covering set of protein family profiles.

  title={Towards a covering set of protein family profiles.},
  author={Andreas Heger and Liisa Holm},
  journal={Progress in biophysics and molecular biology},
  volume={73 5},
Evolutionary classification leads to an economical description of the protein sequence universe because attributes of function and structure are inherited in protein families. Efficient strategies of functional and structural genomics therefore target one representative from each family. Enumerating all families and establishing family membership consistently based on sequence similarities are nontrivial computational problems. Emerging concepts and caveats of global sequence clustering are… CONTINUE READING

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