Towards a better understanding of the different release phases from PLGA microparticles: Dexamethasone-loaded systems.

@article{Gasmi2016TowardsAB,
  title={Towards a better understanding of the different release phases from PLGA microparticles: Dexamethasone-loaded systems.},
  author={Hayet Gasmi and Florence Siepmann and Mazouz Hamoudi and Florence Dan{\'e}de and J Verin and J F Willart and Juergen Siepmann},
  journal={International journal of pharmaceutics},
  year={2016},
  volume={514 1},
  pages={189-199}
}
Dexamethasone-loaded, poly(lactic-co-glycolic acid) (PLGA) microparticles were prepared using an oil-in-water solvent extraction/evaporation method. The drug loading was varied from 2.4 to 61.9%, keeping the mean particle size in the range of 52-61μm. In vitro drug release was characterized by up to 3 phases: (1) an (optional) initial burst release, (2) a phase with an about constant drug release rate, and (3) a final, again rapid, drug release phase. The importance and durations of these… CONTINUE READING
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Importance of PLGA microparticle swelling for the control of prilocaine release

  • H Gasmi, JF Willart, F Danede, MC Hamoudi, J Siepmann, F. Siepmann
  • Journal of Drug Delivery Science and Technology
  • 2015
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