Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.

@article{Hoffman2015TowardsAD,
  title={Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.},
  author={Brenton D Hoffman and Alpha S. Yap},
  journal={Trends in cell biology},
  year={2015},
  volume={25 12},
  pages={
          803-814
        }
}
Cadherin-based cell-cell adhesions are a primary determinant of tissue structure. For several decades, it had been thought that the primary function of these ubiquitous structures was to resist external mechanical loads. Here we review recent evidence that cadherins also couple together the force-generating actomyosin cytoskeletons of neighbouring cells, serve as potent regulators of the actomyosin cytoskeleton, and activate diverse signalling pathways in response to applied load. In… CONTINUE READING
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