Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

@article{Becker2012TowardsAB,
  title={Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs},
  author={Matthew H. Becker and Reid N. Harris and Kevin P. C. Minbiole and Christian Schwantes and Louise A Rollins-Smith and Laura K Reinert and Robert M. Brucker and Rickie J. Domangue and Brian Gratwicke},
  journal={EcoHealth},
  year={2012},
  volume={8},
  pages={501-506}
}
Populations of native Panamanian golden frogs (Atelopus zeteki) have collapsed due to a recent chytridiomycosis epidemic. Reintroduction efforts from captive assurance colonies are unlikely to be successful without the development of methods to control chytridiomycosis in the wild. In an effort to develop a protective treatment regimen, we treated golden frogs with Janthinobacterium lividum, a skin bacterium that has been used to experimentally prevent chytridiomycosis in North American… Expand
The Role of Symbiotic Bacteria in Disease Resistance and Conservation of the Critically Endangered Panamanian Golden Frog
TLDR
This dissertation characterized the bacterial community of A. zeteki and determined if probiotic therapy could be used to prevent chytridiomycosis in this species and found a large proportion of bacteria had the ability to inhibit Bd. Expand
Direct and Indirect Horizontal Transmission of the Antifungal Probiotic Bacterium Janthinobacterium lividum on Green Frog (Lithobates clamitans) Tadpoles
TLDR
Results show that indirect horizontal transmission can be an effective bioaugmentation method to mitigate chytridiomycosis, and future research is needed to determine the best conditions, including the presence of substrates, under which a probiotic can persist on the skin so that bioaugementation becomes a successful strategy. Expand
Soil bioaugmentation with amphibian cutaneous bacteria protects amphibian hosts from infection by Batrachochytrium dendrobatidis
TLDR
Soil bioaugmentation may be a feasible conservation strategy that could protect amphibians susceptible to chytridiomycosis from declines driven by the disease. Expand
Comparison of in vitro methods to inhibit growth of a virulent strain of Batrachochytrium dendrobatidis (Longcore, Pessier, and Nichols 1999)
  • 2020
—A highly virulent genotype of Batrachochytrium dendrobatidis (Bd), the Global Panzootic Lineage (Bd-GPL), is implicated as a major cause of global amphibian population declines. Bd-GPL strain JEL274Expand
The effect of captivity on the cutaneous bacterial community of the critically endangered Panamanian golden frog (Atelopus zeteki)
TLDR
It is demonstrated that host-associated microbial communities can be significantly altered by captive management, but most of the community composition can be preserved. Expand
Surviving Chytridiomycosis: Differential Anti-Batrachochytrium dendrobatidis Activity in Bacterial Isolates from Three Lowland Species of Atelopus
TLDR
Bacterial strains for development of local probiotic treatments against chytridiomycosis are revealed and light is shed on the mechanisms behind the frog-bacteria-pathogen interaction. Expand
Evaluación de la actividad anti batrachochytrium dendrobatidis por parte de la microbiota presente en la piel de dos especies de ranas andinas
Chytridiomycosis is one of the causes of the massive extinction of amphibians worldwide. Despite the lethality that this disease has shown, there are some frog species that coexist with the fungusExpand
Composition of symbiotic bacteria predicts survival in Panamanian golden frogs infected with a lethal fungus
TLDR
A strong link between the structure of these symbiotic microbial communities and amphibian host health in the face of Bd exposure is suggested and a new approach for developing amphibian probiotics is suggested. Expand
A Fungal Pathogen of Amphibians, Batrachochytrium dendrobatidis, Attenuates in Pathogenicity with In Vitro Passages
TLDR
It is hypothesized that the differences in phenotypic performance observed with Atelopus zeteki are rooted in changes of the Bd genome, and future investigations enabled by this study will focus on the underlying mechanisms of Bd pathogenicity. Expand
Genotyping and differential bacterial inhibition of Batrachochytrium dendrobatidis in threatened amphibians in Costa Rica.
TLDR
It is highly relevant to include local isolates and to consider the origin of the microorganisms when performing in vivo infection tests aimed at developing and implementing mitigation strategies for chytridiomycosis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
The Bacterially Produced Metabolite Violacein Is Associated with Survival of Amphibians Infected with a Lethal Fungus
TLDR
It is suggested that a threshold violacein concentration of about 18 μM on a salamander's skin prevents mortality and morbidity caused by B. dendrobatidis, and it is shown that over one-half of individuals in nature support antifungal bacteria that produce Violacein, which suggests that there is a mutualism between violACEin-producing bacteria and P. cinereus. Expand
Proportion of individuals with anti-Batrachochytrium dendrobatidis skin bacteria is associated with population persistence in the frog Rana muscosa
TLDR
Variation in the proportion of individuals with anti-Bd skin bacteria appears to explain why some populations persist when Bd emerges in a population. Expand
Cutaneous Bacteria of the Redback Salamander Prevent Morbidity Associated with a Lethal Disease
TLDR
Results demonstrate that the cutaneous bacterial community of P. cinereus provides protection to the salamander from Bd and that alteration of this community can change disease resistance, Therefore, symbiotic microbes associated with this species appear to be an important component of its innate skin defenses. Expand
Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines
TLDR
It is shown that Bd infection is associated with pathophysiological changes that lead to mortality in green tree frogs (Litoria caerulea), and in diseased individuals, electrolyte transport across the epidermis was inhibited by >50, plasma sodium and potassium concentrations were respectively reduced by ~20% and ~50%, and asystolic cardiac arrest resulted in death. Expand
Amphibian Chemical Defense: Antifungal Metabolites of the Microsymbiont Janthinobacterium lividum on the Salamander Plethodon cinereus
TLDR
The hypothesis that cutaneous, mutualistic bacteria play a role in amphibian resistance to fungal disease is supported and exploitation of this biological process may provide long-term resistance to B. dendrobatidis. Expand
Chytrid fungus infection related to unusual mortalities of Salamandra salamandra and Bufo bufo in the Peñalara Natural Park, Spain
TLDR
According to measures of larval abundances in 1999 and 2003 the population of S. salamandra has suffered a marked decline but no significant trend was observed for B. bufo, and the analysis of the skin of post-metamorphic specimens revealed the presence of chytrid sporangia and discharge tubes in both species. Expand
Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis
TLDR
It is suggested that disease mitigation not focus exclusively on the elimination or containment of the pathogen, or on the captive breeding of amphibian hosts, rather, successful disease mitigation must be context specific with epidemiologically informed strategies to manage already infected populations by decreasing pathogenicity and host susceptibility. Expand
PREDICTED DISEASE SUSCEPTIBILITY IN A PANAMANIAN AMPHIBIAN ASSEMBLAGE BASED ON SKIN PEPTIDE DEFENSES
TLDR
The hypothesis that B. dendrobatidis is a generalist pathogen and that species possessing an innate immunologic defense at the time of disease emergence are more likely to survive is supported. Expand
Symbiotic bacteria contribute to innate immune defenses of the threatened mountain yellow-legged frog, Rana muscosa
TLDR
It is suggested that symbiotic bacteria with the ability to persist in the presence of mucosal peptides may inhibit infection and colonization of the skin by Bd and increase the effectiveness of innate defense mechanisms in the skin. Expand
Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus
TLDR
Adding an antifungal bacterial species, Janthinobacterium lividum, found on several species of amphibians to the skins of the frog Rana muscosa prevented morbidity and mortality caused by the pathogen chytridiomycosis, showing that cutaneous microbes are a part of amphibian' innate immune system, the microbial community structure on frog skins is a determinant of disease outcome and altering microbial interactions onfrog skins can prevent a lethal disease outcome. Expand
...
1
2
3
4
...