Towards a Better Understanding of Beige Adipocyte Plasticity

@article{Paulo2019TowardsAB,
  title={Towards a Better Understanding of Beige Adipocyte Plasticity},
  author={E. Paulo and Biao Wang},
  journal={Cells},
  year={2019},
  volume={8}
}
Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased insulin sensitivity. In this review, we summarize the current knowledge regarding WAT browning, with a special focus on the beige adipocyte… Expand
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References

SHOWING 1-10 OF 112 REFERENCES
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
TLDR
This work aims to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes. Expand
Adaptive thermogenesis in adipocytes: is beige the new brown?
TLDR
A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases. Expand
Cellular Origins of Beige Fat Cells Revisited
TLDR
A unified model in which beige adipocytes (UCP1+ multilocular cells) in rodents initially arise predominantly from progenitors upon the first exposure to cold temperatures and then interconvert between “dormant beige” and “active bege” phenotypes upon subsequent changes in environmental temperature is suggested. Expand
Identification of a natural beige adipose depot in mice
TLDR
TAT is identified as a natural beige adipose depot in mice with a unique molecular profile that does not require peroxisome proliferator-activated receptor α, and it is demonstrated that the master fatty acid oxidation regulator perox is dispensable for maintaining and activating the beige character of tAT. Expand
Brown and beige fat: development, function and therapeutic potential
TLDR
Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease. Expand
The browning of white adipose tissue: some burning issues.
TLDR
It is pointed to the possibility that cause and effect may on occasion be the reverse: browning agents may disrupt, for example, the fur, leading to increased heat loss, increased thermogenic demand to counteract thisHeat loss, and thus, through sympathetic nervous system activation, to enhanced UCP1 expression in white (and brown) adipose tissues. Expand
A smooth muscle-like origin for beige adipocytes.
TLDR
This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes. Expand
The Beige Adipocyte as a Therapy for Metabolic Diseases
  • Fernando Lizcano
  • Biology, Medicine
  • International journal of molecular sciences
  • 2019
TLDR
Some recent observations arising from the unique physiological capacity of these cells are discussed and their possible role as ways to treat obesity and diabetes mellitus type 2 is discussed. Expand
Lsd1 prevents age-programed loss of beige adipocytes
TLDR
Insight is provided into the mechanism controlling the age-related beige-to-white adipocyte transition and Lsd1 is identified as a regulator of beige fat cell maintenance. Expand
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
TLDR
Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. Expand
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