Towards Retinoid Therapy for Alzheimer’s Disease

  title={Towards Retinoid Therapy for Alzheimer’s Disease},
  author={Koichi Shudo and Hiroshi Fukasawa and Madoka Nakagomi and Nobuyuki Yamagata},
  booktitle={Current Alzheimer research},
Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD. 

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