Towards Retinoid Therapy for Alzheimer’s Disease

@inproceedings{Shudo2009TowardsRT,
  title={Towards Retinoid Therapy for Alzheimer’s Disease},
  author={Koichi Shudo and Hiroshi Fukasawa and Madoka Nakagomi and Nobuyuki Yamagata},
  booktitle={Current Alzheimer research},
  year={2009}
}
Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD. 

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References

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Showing 1-10 of 160 references

Immune cells may fend off Alzheimer disease

Nature Medicine • 2007
View 4 Excerpts
Highly Influenced

Neuroinflammatory processes in Parkinson's disease.

Parkinsonism & related disorders • 2005
View 8 Excerpts
Highly Influenced

The transthyretin-retinol-binding protein complex.

Biochimica et biophysica acta • 2000
View 4 Excerpts
Highly Influenced

[Immunological aspects of amyotrophic lateral sclerosis].

Nihon rinsho. Japanese journal of clinical medicine • 1994
View 8 Excerpts
Highly Influenced

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