Towards De Novo Folding of Protein Structures from Cryo-EM 3D Images at Medium Resolutions


Electron Cryo-microscopy (cryo-EM) is an important biophysical technique that produces 3dimensional (3D) images at different resolutions. De novo folding is becoming a promising approach to derive the backbone of proteins from the cryo-EM 3D images at medium resolutions. We summarize our findings in major steps of de novo folding and the challenges from the 


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