Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach.

@article{Joyce2007TowardWC,
  title={Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach.},
  author={Andrew R. Joyce and Bernhard O. Palsson},
  journal={Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques},
  year={2007},
  volume={64},
  pages={265, 267-309}
}
The increasing availability of various system-level, or so-called 'omics', datasets, in concert with existing data from the primary research literature, is facilitating the development of genome-scale metabolic models for many organisms. By incorporating the metabolic reaction stoichiometry as well as other physicochemical properties into systemic network reconstructions, these models account for the constraints that restrict an organism's phenotypic behavior. Accordingly, unlike many… CONTINUE READING

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