Toward understanding the molecular pathology of Huntington's disease.

  title={Toward understanding the molecular pathology of Huntington's disease.},
  author={Cheryl L Wellington and Ryan Remy Brinkman and John Robert O'Kusky and Michael R. Hayden},
  journal={Brain pathology},
  volume={7 3},
Huntington's Disease (HD) is caused by expansion of a CAG trinucleotide beyond 35 repeats within the coding region of a novel gene. Recently, new insights into the relationship between CAG expansion in the HD gene and pathological mechanisms have emerged. Survival analysis of a large cohort of affected and at-risk individuals with CAG sizes between 39 and 50 repeats have yielded probability curves of developing HD symptoms and dying of HD by a certain age. Animals transgenic for the first exon… CONTINUE READING


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