Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.

@article{Zou2007TowardUT,
  title={Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.},
  author={Guozhang Zou and Erik de Leeuw and Chong Li and Marzena Pazgier and Changqing Li and Pengyun Zeng and W Lu and Jacek T Lubkowski and Wuyuan Lu},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 27},
  pages={19653-65}
}
Human defensins are a family of small antimicrobial proteins found predominantly in leukocytes and epithelial cells that play important roles in the innate and adaptive immune defense against microbial infection. The most distinct molecular feature of defensins is cationicity, manifested by abundant Arg and/or Lys residues in their sequences. Sequence analysis indicates that Arg is strongly selected over Lys in alpha-defensins but not in beta-defensins. To understand this Arg/Lys disparity in… CONTINUE READING
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