Toward understanding and exploiting tumor heterogeneity

  title={Toward understanding and exploiting tumor heterogeneity},
  author={Ash A. Alizadeh and Victoria Aranda and Alberto Bardelli and C{\'e}dric Blanpain and Christoph Bock and Christine Borowski and Carlos Caldas and Andrea Califano and Michael Doherty and Markus Elsner and Manel Esteller and Rebecca C Fitzgerald and Jan O. Korbel and Peter Lichter and Christopher E. Mason and Nicholas Navin and Dana Pe'er and Korn{\'e}lia Poly{\'a}k and Charles W. M. Roberts and Lillian L. Siu and Alexandra Snyder and Hannah Stower and Charles Swanton and Roel G W Verhaak and Jean Claude Zenklusen and Johannes Zuber and Jessica Zucman-Rossi},
  journal={Nature Medicine},
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational… CONTINUE READING
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