Toward understanding Machado-Joseph disease.

Abstract

Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is the most common inherited spinocerebellar ataxia and one of many polyglutamine neurodegenerative diseases. In MJD, a CAG repeat expansion encodes an abnormally long polyglutamine (polyQ) tract in the disease protein, ATXN3. Here we review MJD, focusing primarily on the… (More)
DOI: 10.1016/j.pneurobio.2011.11.006

Topics

  • Presentations referencing similar topics