Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling

@article{Lange2005TowardTP,
  title={Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling},
  author={Elizabeth C. de Lange and Paulien G. M. Ravenstijn and Dorien Groenendaal and Tamara J. van Steeg},
  journal={The AAPS Journal},
  year={2005},
  volume={7},
  pages={E532-E543}
}
Our ultimate goal is to develop mechanism-based pharmacokinetic (PK)-pharmacodynamic (PD) models to characterize and to predict CNS drug responses in both physiologic and pathologic conditions. To this end, it is essential to have information on the biophase pharmacokinetics, because these may significantly differ from plasma pharmacokinetics. it is anticipated that biophase kinetics of CNS drugs are strongly influenced by transport across the blood-brain barrier (BBB). The special role of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 123 references

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain

  • EC De Lange, M. Danhof
  • Clin Pharmacokinet
  • 2002
Highly Influential
5 Excerpts

The influence of an increase in plasma protein binding on the pharmacokinetics and pharmacodynamics of S(-)-Propranolol. Poster presentation at the Population Approach

  • T van Steeg, F Macintyre, M Danhof, ECM. de Lange
  • Group Europe (PAGE),
  • 2005

Towards a mechanism-based pharmacokinetic/pharmacodynamic model for opioids: influence of P-glycoprotein and apparent permeability in vitro

  • D Groenendaal, D de Mik, G Nicholls
  • Submitted,
  • 2005
1 Excerpt

Blood-brain barrier permeability in Parkinson s disease progression using the rotenone rat model

  • P Ravenstijn, M Merlini, M Hameetman
  • Poster presentation at the 4th International…
  • 2004

Similar Papers

Loading similar papers…