Toward the practical implementation of eye-related bioavailability prediction models.

@article{Pepi2014TowardTP,
  title={Toward the practical implementation of eye-related bioavailability prediction models.},
  author={Ivan Pepi{\'c} and Jasmina Lovri{\'c} and Biserka Cetina-{\vC}i{\vz}mek and Stephan Reichl and Jelena Filipovi{\'c}-Gr{\vc}i{\'c}},
  journal={Drug discovery today},
  year={2014},
  volume={19 1},
  pages={31-44}
}
The development and registration of reformulated ophthalmic products (OPs) requires eye-related bioavailability (BA) assessments. Common BA algorithms associated with other routes of application, such as the oral route, cannot be easily applied to eye-related BA testing. Here, we provide an analysis of the current literature and suggestions for further directions in the development of high-capacity, cost-effective, and highly predictive nonclinical models of eye-related drug BA. One, or a… CONTINUE READING

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