Toward the fast blind docking of a peptide to a target protein by using a four-body statistical pseudo-potential

@article{Aita2010TowardTF,
  title={Toward the fast blind docking of a peptide to a target protein by using a four-body statistical pseudo-potential},
  author={Takuyo Aita and Koichi Nishigaki and Yuzuru Husimi},
  journal={Computational biology and chemistry},
  year={2010},
  volume={34 1},
  pages={
          53-62
        }
}
In vitro molecular evolution creates a lot of peptide aptamers that bind to each target protein. In many cases, their binding sites on a protein surface are not known. Then, predicting the binding sites through computation within a reasonable time is desirable. With this aim, we have developed a novel system of fast and robust blind docking of a peptide to a fixed protein structure at low computational costs. Our algorithm is based on the following scheme. Representing each of the amino acid… CONTINUE READING

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