Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.

@article{Williams2012TowardTE,
  title={Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.},
  author={Hywel D Williams and Mette Uhre Anby and Philip Jonas Sassene and Karen Kleberg and Jean-Claude Bakala-N'Goma and Marilyn Calderone and Vincent Jannin and Annabel Igonin and Anette Partheil and Delphine Marchaud and Eduardo Jule and J. Vertommen and Mario Maio and Ross D Blundell and Hassan Benameur and Fr{\'e}d{\'e}ric Carri{\`e}re and Anette M{\"u}llertz and Colin W. Pouton and Christopher J. H. Porter},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 11},
  pages={
          3286-300
        }
}
The LFCS Consortium was established to develop standardized in vitro tests for lipid-based formulations (LBFs) and to examine the utility of these tests to probe the fundamental mechanisms that underlie LBF performance. In this publication, the impact of bile salt (sodium taurodeoxycholate, NaTDC) concentration and drug loading on the ability of a range of representative LBFs to generate and sustain drug solubilization and supersaturation during in vitro digestion testing has been explored and… CONTINUE READING

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