Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.

@article{Hyman2010TowardTD,
  title={Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.},
  author={Lynne M Hyman and Clifton J. Stephenson and Marina G. Dickens and Ken D. Shimizu and Katherine J. Franz},
  journal={Dalton transactions},
  year={2010},
  volume={2},
  pages={
          568-76
        }
}
A fluorescent sensor prochelator, FlamB (fluorescein hydrizido 2-imidophenylboronic ester), has been developed that selectively probes for copper under conditions of oxidative stress. High levels of hydrogen peroxide trigger the release of a boronic ester masking group from the prochelator to unveil a metal chelator, FlamS (fluorescein hydrizido 2-imidophenol), that provides a modest fluorescence increase in response to Cu(2+) but not other metal ions. X-Ray crystal structures of FlamB, FlamS… 
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References

SHOWING 1-10 OF 31 REFERENCES
A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.
TLDR
The pro-chelate approach of BSIH represents a promising strategy for chelating a specific pool of detrimental metal ions without disturbing healthy metal ion distribution.
Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.
TLDR
Both the rate of pro-chelator to chelator conversion as well as the metal binding affinity of the chelator influence the overall ability of these molecules to inhibit hydroxyl radical formation catalyzed by iron or copper in the presence of hydrogen peroxide and ascorbic acid.
Highly sensitive and fast responsive fluorescence turn-on chemodosimeter for Cu2+ and its application in live cell imaging.
TLDR
A rhodamine B derivative 4 containing a highly electron-rich S atom has been synthesized as a fluorescence turn-on chemodosimeter for Cu(2+), which can selectively recognize Cu( 2+) in aqueous media in the presence of other trace metal ions in organisms.
Sensitive Determination of Cobalt(II) Using a Spiro Fluorescein Hydrazide as a Chemiluminogenic Reagent
Abstract.A novel chemiluminogenic reagent, refered to as spiro form fluorescein hydrazide, was synthesized, and its application to chemiluminescence (CL) determination of Co2+ is described. The
New fluorescent rhodamine hydrazone chemosensor for Cu(II) with high selectivity and sensitivity.
TLDR
A new fluorescent probe was synthesized and displayed selective Cu( II)-amplified absorbance and fluorescence emission above 500 nm in neutral buffered media and the detection of Cu(II) by 1 at a lower micromolar level was successful even in buffered water.
Fluorophotometric determination of hydrogen peroxide and other reactive oxygen species with fluorescein hydrazide (FH) and its crystal structure.
TLDR
The fluorophotometric determination of hydrogen peroxide and other reactive oxygen species and other ROS and fluorescein hydrazide and the characterization of FH were proposed, and interesting information was obtained with regard to the relationship between the chemical structure and fluorescence.
...
1
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