Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists

  title={Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists},
  author={Patricia H. Reggio},
  journal={Drug Development Research},
  • P. Reggio
  • Published 1 December 2009
  • Biology, Chemistry
  • Drug Development Research
The cannabinoid CB1 receptor belongs to Class A of the G‐protein‐coupled receptor (GPCR) family. The high constitutive activity of CB1 facilitates inverse agonism at this receptor, and CB1 inverse agonists/antagonists have recently been considered for the treatment of obesity and metabolic syndrome. GPCRs are assumed to have a common topology and to share a common molecular activation mechanism involving their intracellular domains. However, each individual receptor will also have a molecular… 
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