• DOI:10.1002/DDR.20337
Corpus ID: 83478850

Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists

@article{Reggio2009TowardTD,
  title={Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists},
  author={P. Reggio},
  journal={Drug Development Research},
  year={2009},
  volume={70}
}

• P. Reggio
• Published 2009
• Biology
• Drug Development Research

The cannabinoid CB1 receptor belongs to Class A of the G‐protein‐coupled receptor (GPCR) family. The high constitutive activity of CB1 facilitates inverse agonism at this receptor, and CB1 inverse agonists/antagonists have recently been considered for the treatment of obesity and metabolic syndrome. GPCRs are assumed to have a common topology and to share a common molecular activation mechanism involving their intracellular domains. However, each individual receptor will also have a molecular… Expand

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