Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.

@article{Comelli2007TowardTD,
  title={Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.},
  author={Maria Cristina Comelli and Ulrich Mengs and Carl Schneider and Marco Prosdocimi},
  journal={Integrative cancer therapies},
  year={2007},
  volume={6 2},
  pages={120-9}
}
Silymarin, the active extract from milk thistle, has been extensively used in patients with liver disease of different etiology. Although silymarin is a complex of 7 flavonolignans and polyphenols, silibinin is usually regarded as the most active component. In vitro and in vivo studies indicate that silymarin and silibinin protect the liver from oxidative stress and sustained inflammatory processes, mainly driven by Reactive Oxygen Species (ROS) and secondary cytokines. Oxidative stress and… CONTINUE READING
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