Toward the Emergence of Nanoneurosurgery: Part III—Nanomedicine: Targeted Nanotherapy, Nanosurgery, and Progress Toward the Realization of Nanoneurosurgery

  title={Toward the Emergence of Nanoneurosurgery: Part III—Nanomedicine: Targeted Nanotherapy, Nanosurgery, and Progress Toward the Realization of Nanoneurosurgery},
  author={Scott P. Leary and Charles Y. Liu and Michael L. J. Apuzzo},
THE NOTION OF nanotechnology has evolved since its inception as a fantastic conceptual idea to its current position as a mainstream research initiative with broad applications among all divisions of science. In the first part of this series, we reviewed the structures and principles that comprise the main body of knowledge of nanoscience and nanotechnology. In the second part, we discussed applications of nanotechnology to the emerging field of nanomedicine, with specific attention on medical… 

Toward the emergence of nanoneurosurgery: part III--nanomedicine: targeted nanotherapy, nanosurgery, and progress toward the realization of nanoneurosurgery.

Femtosecond laser systems, nanoneedles, and nanotweezers are presented as technologies that are operational at the nanoscale level and have the potential to revolutionize the practice of neurosurgery in a profound and momentous way.

Nanotechnology Challenges; Nanomedicine: Nanorabots

Nanorobots have remarkable applications in health care and environment monitoring and will be useful or applicable in treating various diseases like cance r, diabetes, tumour or respiration related diseases.

Neuroprotection at the Nanolevel—Part I

  • R. Andrews
  • Biology
    Annals of the New York Academy of Sciences
  • 2007
The realm of nanotechnology and some unique properties of nanomaterials is introduced and several of the nanotechniques in development that are most likely to affect neuroprotection at the nanolevel are reviewed.

Nanobioscience Based on Nanorobotic Manipulation

In this chapter,we present a summary of nanorobotic manipulations under various microscopes and their nanobioscience applications. Until now, nanomanipulation is mainly applied to the scientific

Nanorobots: The Emerging tools in Medicinal

In this review, nanorobots and its tools, mechanism, approaches and main futuristic applications of the same which mainly useful for medicinal and to develop new formulations related to nanotechnology to cure the major diseases.

Smart Nano-systems for Tumour Cellular Diagnoses and Therapies

This chapter reviewes recent nanotechnological applications in the field of non-ionizing cellular imaging and “personalized” therapies, with special focus on innovative strategies for selective cancer detection and treatment.

Modeling the structure‐property relationships of nanoneedles: A journey toward nanomedicine

Due to the apolar characteristics of CNNs and their ability to carry ionic species, they would be suitable to act as drug carriers through nonpolar biologic media, and might act as semiconductors at the limit of infinite‐length.

Nanoparticles in Drug Delivery and Cancer Therapy: The Giant Rats Tail

This review addresses the advancement of nanoparticles in drug delivery and in cancer therapy with a focus on drug delivery using nanovectors and hybrid nanoparticles.

Nanotechnology Applications in Vascular Disease

Current and emerging nanotechnologies aimed at vascular disease are highlighted and hold great promise for improving the stand of care.



Toward the emergence of nanoneurosurgery: part II--nanomedicine: diagnostics and imaging at the nanoscale level.

The applications of nanotechnology to biological systems that will undoubtedly transform the foundations of disease diagnosis, treatment, and prevention in the future are reviewed and discussed.

Toward the Emergence of Nanoneurosurgery: Part I—Progress in Nanoscience, Nanotechnology, and the Comprehension of Events in the Mesoscale Realm

Specific attention is given to the developments in imaging, fabrication, nanostructures, nanoelectromechanical systems, molecular manufacturing, nanocomputation, and emerging physical and chemical concepts in mesoscale, as they will establish foundations for the realization of nanomedicine and nanoneurosurgery.

Nanotech approaches to drug delivery and imaging.

The Synthesis and Testing of Anti-Cancer Therapeutic Nanodevices

The work to date has demonstrated the feasibility of the nano-device concept in actual cancer cells in vitro and progress has been made on the specifically triggered release of the therapeutic agent within a tumor using high-energy lasers.

The impact of nanobiotechnology on the development of new drug delivery systems.

This review discusses nanoparticular drug carrier systems with the exception of liposomes used today, and what the potential and limitations of nanoparticles in the field of pharmaceutical biotechnology are.

Bioartificial organs in the twenty-first century: nanobiological devices.

  • A. Prokop
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 2001
The nanoelectronic interface and delivery nanosystems will be used for sensing, feedback, control, and analysis of function of bioartificial organs.

Bioartificial Organs in the Twenty‐first Century

The nanoelectronic interface and delivery nanosystems will be used for sensing, feedback, control, and analysis of function of bioartificial organs.

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

  • L. HirschR. Stafford J. West
  • Engineering
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.

Small-scale systems for in vivo drug delivery

Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device, but current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary.

Nanoparticles in cancer therapy and diagnosis.