Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validation.

@article{Kleinstein2001TowardQS,
  title={Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validation.},
  author={Steven H. Kleinstein and Jai Prakash Singh},
  journal={Journal of theoretical biology},
  year={2001},
  volume={211 3},
  pages={253-75}
}
As models of immune system dynamics are developed, it is important to validate them with specific experimental data in order to understand their shortcomings and guide them toward becoming predictive. In this paper, we examine whether a particular mathematical model of germinal center dynamics, proposed by Oprea and Perelson, can reproduce experimental data from two specific primary responses, namely those directed against the haptens 2-phenyl-5-oxazolone and (4-hydroxy-3-nitrophenyl)acetyl. We… CONTINUE READING

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