Toward predictive models for drug-induced liver injury in humans: are we there yet?

@article{Chen2014TowardPM,
  title={Toward predictive models for drug-induced liver injury in humans: are we there yet?},
  author={Minjun Chen and Halil Bisgin and Lillian Tong and Huixiao Hong and Hong Fang and J{\"u}rgen Borlak and Weida Tong},
  journal={Biomarkers in medicine},
  year={2014},
  volume={8 2},
  pages={
          201-13
        }
}
Drug-induced liver injury (DILI) is a frequent cause for the termination of drug development programs and a leading reason of drug withdrawal from the marketplace. Unfortunately, the current preclinical testing strategies, including the regulatory-required animal toxicity studies or simple in vitro tests, are insufficiently powered to predict DILI in patients reliably. Notably, the limited predictive power of such testing strategies is mostly attributed to the complex nature of DILI, a poor… CONTINUE READING

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