Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.

@article{Harrison2011TowardM,
  title={Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.},
  author={Tyler J Harrison and Stephen Ho and James L Leighton},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 19},
  pages={7308-11}
}
A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence.