Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects

@article{Liu2014TowardME,
  title={Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects},
  author={Yanfeng Liu and Hyun-dong Shin and Jianghua Li and Long Liu},
  journal={Applied Microbiology and Biotechnology},
  year={2014},
  volume={99},
  pages={1109-1118}
}
Metabolic engineering facilitates the rational development of recombinant bacterial strains for metabolite overproduction. Building on enormous advances in system biology and synthetic biology, novel strategies have been established for multivariate optimization of metabolic networks in ensemble, spatial, and dynamic manners such as modular pathway engineering, compartmentalization metabolic engineering, and metabolic engineering guided by genome-scale metabolic models, in vitro reconstitution… 

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