Toward genetic transformation of mitochondria in mammalian cells using a recoded drug-resistant selection marker.

@article{Yoon2011TowardGT,
  title={Toward genetic transformation of mitochondria in mammalian cells using a recoded drug-resistant selection marker.},
  author={Young geol Yoon and Michael Duane Koob},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  year={2011},
  volume={38 4},
  pages={173-9}
}
Due to technical difficulties, the genetic transformation of mitochondria in mammalian cells is still a challenge. In this report, we described our attempts to transform mammalian mitochondria with an engineered mitochondrial genome based on selection using a drug resistance gene. Because the standard drug-resistant neomycin phosphotransferase confers… CONTINUE READING