Toward functional genomics of flow-induced outward remodeling of resistance arteries.

  title={Toward functional genomics of flow-induced outward remodeling of resistance arteries.},
  author={Jo G. R. De Mey and Paul M. H. Schiffers and Rob H. P. Hilgers and Marijke M W Sanders},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={288 3},
In resistance-sized arteries, a chronic increase in blood flow leads to increases in arterial structural luminal diameter and arterial wall mass. In this review, we summarize recent evidence that outward remodeling of resistance arteries 1) can help maintain and restore tissue perfusion, 2) is not intimately related to flow-induced vasodilatation, 3) involves transient dedifferentiation and turnover of arterial smooth muscle cells, and 4) is preceded by increased expression of matricellular… CONTINUE READING


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Chronic NG-nitro-L-arginine methyl ester treatment does not prevent flow-induced remodeling in mesenteric feed arteries and arcading arterioles

  • DL Ceiler, De Mey JGR
  • Arterioscler Thromb Vasc Biol
  • 2000
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