Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation.

@article{Yuan2010TowardFS,
  title={Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation.},
  author={Yu Hong Yuan and Jin Chen and Qian Wan and Rebecca M. Wilson and Samuel J Danishefsky},
  journal={Biopolymers},
  year={2010},
  volume={94 4},
  pages={373-84}
}
Traditionally, in the pharma sciences, there has been an unstated but operative bifurcation into small molecules and biologics. Small molecules were seen to be, at the discovery level, in the province of chemistry, based on targets provided through biology. By contrast, "biologics" were seen to arise solely from the province of biology exploiting its accessible replicative mechanisms. Our laboratory has been dedicated to the proposition that explosive advances in chemical synthesis have been… CONTINUE READING