Toward antiviral strategies that resist viral escape.

@article{Endy2000TowardAS,
  title={Toward antiviral strategies that resist viral escape.},
  author={Drew Endy and John Yin},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 4},
  pages={1097-9}
}
We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance. 
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Development and application of a genetically-structured simulation for bacteriophage T7

  • D. Endy
  • Ph.D. thesis. Dartmouth College,
  • 1997

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