Toward an understanding of the Cdc48/p97 ATPase

@inproceedings{Bodnar2017TowardAU,
  title={Toward an understanding of the Cdc48/p97 ATPase},
  author={Nicholas O. Bodnar and Tom A Rapoport},
  booktitle={F1000Research},
  year={2017}
}
A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes. For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), Cdc48/p97 pulls polyubiquitinated, misfolded proteins out of the ER and transfers them to the proteasome. Cdc48/p97 consists of an N-terminal domain and two ATPase domains (D1 and D2). Six Cdc48 monomers form a double… CONTINUE READING