Toward an understanding of NKT cell biology: progress and paradoxes.

  title={Toward an understanding of NKT cell biology: progress and paradoxes.},
  author={Mitchell Kronenberg},
  journal={Annual review of immunology},
Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an invariant T cell antigen receptor (TCR) alpha chain, and unusual requirements for thymic selection. They rapidly produce many cytokines after stimulation and thus influence diverse immune responses and pathogenic processes. Because of intensive research effort, we have learned much about factors promoting the… CONTINUE READING
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