Toward an integrated phenotype in pre-NIDDM.

  title={Toward an integrated phenotype in pre-NIDDM.},
  author={Richard N Bergman and Richard M. Watanabe and Kerstin Rebrin and Marilyn Ader and Garry M. Steil},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  volume={13 9 Suppl 6},
The search for the genetic basis of NIDDM has magnified the need for an efficient representation of the pre-NIDDM phenotype. The overall goal is to relate specific mutations on the genome to specific changes in physiologic function which lead to NIDDM. Unfortunately, there is still not a clear understanding of the molecular cause of NIDDM in most individuals. Therefore, one must take an alternative approach: to express in quantitative terms the various tissue processes which determine the… CONTINUE READING


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