Toward an efficient synthesis of taxane analogs by dienyne ring-closing metathesis.

@article{Aldegunde2008TowardAE,
  title={Toward an efficient synthesis of taxane analogs by dienyne ring-closing metathesis.},
  author={Mar{\'i}a Jos{\'e} Aldegunde and Luis Castedo and Juan R. Granja},
  journal={Organic letters},
  year={2008},
  volume={10 17},
  pages={3789-92}
}
An efficient tandem ring-closing dienyne metathesis of dienynes derived from cyclohex-2-enone affords the [5.3.1] carbon framework characteristic of taxanes in a single-step process. Further stereoselective functionalizations of the resulting [5.3.1] carbon framework lead to an advanced intermediate in a novel synthetic strategy for taxane analogs.