Toward an accurate theoretical framework for describing ensembles for proteins under strongly denaturing conditions.

@article{Tran2006TowardAA,
  title={Toward an accurate theoretical framework for describing ensembles for proteins under strongly denaturing conditions.},
  author={Hoang T. Tran and Rohit V. Pappu},
  journal={Biophysical journal},
  year={2006},
  volume={91 5},
  pages={1868-86}
}
Our focus is on an appropriate theoretical framework for describing highly denatured proteins. In high concentrations of denaturants, proteins behave like polymers in a good solvent and ensembles for denatured proteins can be modeled by ignoring all interactions except excluded volume (EV) effects. To assay conformational preferences of highly denatured proteins, we quantify a variety of properties for EV-limit ensembles of 23 two-state proteins. We find that modeled denatured proteins can be… CONTINUE READING

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