Corpus ID: 212560339

Toward an Endothelial-Cell Covered Mechanical Valve ; Surface Re-Engineering and Bioreactor Testing of Mechanical Heart Valves

  title={Toward an Endothelial-Cell Covered Mechanical Valve ; Surface Re-Engineering and Bioreactor Testing of Mechanical Heart Valves},
  author={Leslie Neil Sierad and Eliza Laine Shaw and Ryan D. Launius and Shannon McBride and Cassie Storholt and Ryan Poole and Daniel Spence and Katie Miller and Lauren Sosdian and Kaity Allen and Lauren Burton and Anita Iari and Jiro Nagatomi and Dan Simionescu},
Mechanical valve replacements for diseased heart valves have excellent long-term durability, but necessitate a lifetime anticoagulation regimen. We aimed to create a more hemocompatible device by modifying the leaflet surfaces to promote adherence and retention of endothelial cells under physiological shear forces. St. Jude Medical mechanical valves were autoclaved, plasma treated, coated with a collagen/fibronectin solution, and seeded with porcine aortic endothelial cells. The next day, the… Expand

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Endothelialization of cardiovascular devices.
  • S. Jana
  • Medicine
  • Acta biomaterialia
  • 2019
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