Toward a universal influenza virus vaccine: prospects and challenges.

  title={Toward a universal influenza virus vaccine: prospects and challenges.},
  author={Natalie Pica and P. Palese},
  journal={Annual review of medicine},
Current influenza virus vaccines are annually reformulated to elicit protection by generating an immune response toward the virus strains that are predicted to circulate in the upcoming influenza season. These vaccines provide limited protection in cases of antigenic mismatch, when the vaccine and the circulating viral strains differ. The emergence of unexpected pandemic viruses presents an additional challenge to vaccine production. To increase influenza virus preparedness, much work has been… CONTINUE READING
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