Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings

@article{Misiak2017TowardAU,
  title={Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings},
  author={Błażej Misiak and Maja Krefft and Tomasz Bielawski and Ahmed A. Moustafa and Maria Małgorzata Sąsiadek and Dorota Frydecka},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2017},
  volume={75},
  pages={393-406}
}
HIGHLIGHTSChildhood traumatic events increase a risk of psychosis.Childhood trauma might be associated with a specific psychosis manifestation.Childhood adversities trigger specific biological alterations in psychosis.Childhood trauma might predict poor prognosis in psychotic disorders.Psychosis with positive history of childhood trauma might be a distinct phenotype. ABSTRACT There is a growing body of research focused on the relationship between childhood trauma and the risk of developing… Expand
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Psychotic experiences are common in the general population and have been reported in children, adolescents, and adults. Childhood trauma, i.e. maltreatment with the intention to harm, has been… Expand
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Overall, the current evidence suggests that CA may be associated with psychosis largely independently of genetic vulnerabilities, as well as the mediating role of attachment and mood symptoms, which is suggestive of an affective pathway between CA and psychosis across the continuum from subclinical experiences to diagnosable disorder. Expand
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The findings support the notion that sex differences in stress vulnerability account for the relatively poor illness course in male psychosis patients and suggest differences in CT experiences in male and female FEP patients, with a more pronounced impact on longer-term outcome in male patients. Expand
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Abstract Adverse childhood experiences are frequently present in patients with mental disorders, including those with schizophrenia. Whereas an impact of childhood adversities on psychopathology and… Expand
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TLDR
Adverse childhood experiences among people with psychosis are common, as are subsequent psychosocial stressors, and longitudinal research is needed to better understand these relationships and evaluate the effectiveness of preventative interventions in high-risk groups. Expand
Childhood Trauma and Psychosis: An Updated Review.
TLDR
There is growing evidence to support the link between childhood trauma and psychosis, and gender differences in the influence of childhood trauma on the course of psychotic illnesses, appearing to be more profound in girls and women. Expand
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TLDR
Overall, a majority of studies reported that patients who experienced CT displayed deficits in general cognitive ability compared to patients with psychosis without such a history, and associations between CT and other cognitive function were more mixed. Expand
Traumagenics: At the intersect of childhood trauma, immunity and psychosis
Early childhood trauma, including physical, sexual or emotional abuse, neglect, harm or threat of harm, is associated with adulthood dysregulation of the immune system. Trauma can induce chronic… Expand
Childhood adversities and clinical symptomatology in first-episode psychosis
TLDR
High levels of mood and anxiety symptoms in patients with FEP may be related to cumulative exposure to childhood adversities, which should be taken into account in the treatment for FEP. Expand
Childhhood Trauma in Schizophrenia Spectrum Disorders: Dissociative, Psychotic Symptoms, and Suicide Behavior.
TLDR
A cross-sectional study with 54 patients with schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder) obtained sociodemographic data, as well as data on CT, dissociation, suicide history, and intensity of positive and negative psychotic symptoms. Expand
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