Toward a system-level understanding of microRNA pathway via mathematical modeling

@article{Wang2010TowardAS,
  title={Toward a system-level understanding of microRNA pathway via mathematical modeling},
  author={Xia Wang and Yan Li and Xue Xu and Yong-Hua Wang},
  journal={Bio Systems},
  year={2010},
  volume={100 1},
  pages={31-8}
}
The microRNA (miRNA) pathway plays multiple roles in regulating mechanisms controlling both physiological and pathological processes such as the cell proliferation and cancers. But little is known about the dynamic properties, key rate-limiting steps as well as the stochastic noise in this pathway. Presently, a system-theoretic approach was presented to analyze and quantitative modeling of a generic miRNA pathway, which can be implemented deterministically and stochastically. Our results show… CONTINUE READING

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