Toward a realistic model of mutations affecting fitness.

@article{Keightley2003TowardAR,
  title={Toward a realistic model of mutations affecting fitness.},
  author={Peter D. Keightley and Michael Lynch},
  journal={Evolution; international journal of organic evolution},
  year={2003},
  volume={57 3},
  pages={683-5; discussion 686-9}
}
Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious. 

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