Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.

  title={Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.},
  author={Imad Ghorayeb and P O Fernagut and Incarnation Aubert and Erwan B{\'e}zard and Werner Poewe and Gregor Karl Wenning and Francois Tison},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={15 3},
We developed a primate model of striatonigral degeneration (SND), the neuropathology underlying levodopa-unresponsive parkinsonism associated with multiple systemic atrophy (MSA-P), by sequential systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3-nitropropionic acid (3NP) in a Macaca fascicularis monkey. L-Dopa-responsive parkinsonian features emerged after MPTP injections. Subsequent chronic 3NP administration aggravated the motor symptoms and abolished the L… CONTINUE READING


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