Toward a neuroimaging treatment selection biomarker for major depressive disorder.

@article{McGrath2013TowardAN,
  title={Toward a neuroimaging treatment selection biomarker for major depressive disorder.},
  author={Callie L McGrath and Mary E. Kelley and Paul E. Holtzheimer and Boadie W. Dunlop and W Edward Craighead and Alexandre Rosa Franco and R. Cameron Craddock and Helen S. Mayberg},
  journal={JAMA psychiatry},
  year={2013},
  volume={70 8},
  pages={821-9}
}
IMPORTANCE Currently, fewer than 40% of patients treated for major depressive disorder achieve remission with initial treatment. Identification of a biological marker that might improve these odds could have significant health and economic impact. OBJECTIVE To identify a candidate neuroimaging "treatment-specific biomarker" that predicts differential outcome to either medication or psychotherapy. DESIGN Brain glucose metabolism was measured with positron emission tomography prior to… CONTINUE READING