Toward a molecular definition of long-term memory storage.
@article{Bailey1996TowardAM, title={Toward a molecular definition of long-term memory storage.}, author={Craig H. Bailey and Dusan Bartsch and Eric R. Kandel}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1996}, volume={93 24}, pages={ 13445-52 } }
The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory processes, ranging in complexity from those produced by simple forms of implicit learning in invertebrates to those produced by more complex forms of explicit learning in mammals, suggest that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP…
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References
SHOWING 1-10 OF 67 REFERENCES
Structural changes accompanying memory storage.
- Biology, PsychologyAnnual review of physiology
- 1993
The recent evidence for structural changes in learning is considered by considering the structural changes that accompany long-term memory and how they compare with the de novo synapse formation and synaptic pruning that occur during development.
A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia
- BiologyNeuron
- 1995
CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila
- BiologyCell
- 1995
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.
- BiologyScience
- 1993
Activation of PKA may be a component of the mechanism that generates L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L- LTP, which was blocked by inhibitors of protein synthesis.
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
- Biology, PsychologyCell
- 1994
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
- BiologyCell
- 1994
Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1993
It is suggested that degradation is initiated by cAMP, which causes the holoenzyme to dissociate and, further, that the altered R-to-C ratio in Aplysia sensory neurons is maintained in long-term facilitation by newly synthesized proteins that help target R subunits for accelerated degradation.
Long-term sensitization in Aplysia: biophysical correlates in tail sensory neurons.
- BiologyScience
- 1987
The results indicate that one mechanism for the storage of long-term sensitization is the regulation of membrane currents that influence the characteristics of the action potential and the excitability of individual neurons.
Morphological basis of long-term habituation and sensitization in Aplysia.
- Biology, PsychologyScience
- 1983
The morphological basis of the persistent synaptic plasticity that underlies long-term habituation and sensitization of the gill withdrawal reflex in Aplysia californica was explored by examining the fine structure of sensory neuron presynaptic terminals in control animals and in animals whose behavior had been modified by training.