Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions.

@article{Guest2011TowardAM,
  title={Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions.},
  author={Will Guest and Steven S. Plotkin and Neil Cashman},
  journal={Journal of toxicology and environmental health. Part A},
  year={2011},
  volume={74 2-4},
  pages={
          154-60
        }
}
Despite extensive investigation, many features of prion protein misfolding remain enigmatic. Physicochemical variables known to influence misfolding are reviewed to help elucidate the mechanism of prionogenesis and identify salient features of PrP(Sc), the misfolded conformer of the prion protein. Prospective work on refinement of candidate PrP(Sc) models based on thermodynamic considerations will help to complete atomic-scale structural details missing from experimental studies and may explain… CONTINUE READING
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