Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models

@article{Sizemore2000TowardAM,
  title={Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models},
  author={Glen M. Sizemore and Thomas J Martin},
  journal={Psychopharmacology},
  year={2000},
  volume={153},
  pages={57-66}
}
Rationale: The interpretation of dose-effect functions for self-administered drugs remains elusive. Since, for self-administered drugs, the amount of drug in an animal depends on its behavior, a mathematical theory of drug self-administration must include terms relevant to receptor theory, as well as a description of how an organism's behavior affects the amount of drug in the animal over time. Objective: A theory was constructed in which the ability of a dose to maintain responding was… CONTINUE READING