Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models

@article{Sizemore2000TowardAM,
  title={Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models},
  author={G. M. Sizemore and T. J. Martin},
  journal={Psychopharmacology},
  year={2000},
  volume={153},
  pages={57-66}
}
  • G. M. Sizemore, T. J. Martin
  • Published 2000
  • Psychology, Medicine
  • Psychopharmacology
  • Abstract. Rationale: The interpretation of dose-effect functions for self-administered drugs remains elusive. Since, for self-administered drugs, the amount of drug in an animal depends on its behavior, a mathematical theory of drug self-administration must include terms relevant to receptor theory, as well as a description of how an organism's behavior affects the amount of drug in the animal over time. Objective: A theory was constructed in which the ability of a dose to maintain responding… CONTINUE READING

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