Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond.

@article{Giannoukakis2008TowardAC,
  title={Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond.},
  author={Nick Giannoukakis and Brooke Elizabeth Phillips and Massimio Trucco},
  journal={Pediatric diabetes},
  year={2008},
  volume={9 3 Pt 2},
  pages={
          4-13
        }
}
Insulin has been the gold standard therapy for diabetes since its discovery and commercial availability. It remains the only pharmacologic therapy for type 1 diabetes (T1D), an autoimmune disease in which autoreactive T cells specifically kill the insulin-producing beta cells. Nevertheless, not even molecularly produced insulin administered four or five times per day can provide a physiologic regulation able to prevent the complications that account for the morbidity and mortality of diabetic… CONTINUE READING
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